Tubular, Cystic & Drug Nephropathy

1.14-year-old girl came with upper abdominal pain and repeated vomiting. She was recently noticed to have polyuria and weight loss. Examination revealed fruity odour in the month apart from severe dehydration.  Most probable diagnosis  Evaluate for alternative possibilities  Management of current complication  Treatment of underlying disease

1.Nephrotoxic drugs

2.Urinary abnormality in diabetic kidney disease

3.Drug induced renal injury

4.ADPKD (autosomal dominant polycystic kidney disease)

5.Polyuria

6.List causes of polyuria

7.Mention four manifestations of adult polycystic kidney disease

1.Assertion (A): The passing more than 3litra/day of urine is called as polyuria

• Reason(R): Polyuria is due to defect in aquaporin receptors and excretion of non absorbable solutes through kidney
• a) Both A and R are true and R is the correct explanation of A
• b) Both A and R are true but R is not the correct explanation of A
• c) A is true but R is false
• d) A is false but R is true