Bleeding & Coagulation Disorders

1.Immune thrombocytopaenic purpura

2.Pathogenesis and lab diagnosis of Disseminated intravascular coagulation

3.Haemophilia A

4.Pictorially describe the extrinsic and intrinsic pathway of coagulation. Mention the tests used in their assessment with their normal ranges

5.A 15 years old boy was admitted for severe hemorrhage after trauma. On examination he had haemarthrosis of large joints and muscle hematomas. Some of the family members have similar clinical manifestations. Answer the following: • What is the provisional diagnosis. • Which are the four lab investigations to be done to confirm the diagnosis. Explain the changes in these investigations expected in this patient • What is the pathogenesis of this disease

1.Idiopathic thrombocytopenic purpura

2.Hemophilia

3.Enlist four common anticoagulants used in a Hematology laboratory

4.Etiopathogenesis of Idiopathic thrombocytopenic purpura

5.Immune thrombocytopenic purpura (ITP)

6.Lab diagnosis of Hemophilia A

7.Lab diagnosis of immune thrombocytopenic purpura

1.Two causes for thrombocytopenia

2.Enumerate two anticoagulants

3.What is thrombocytopenia. Enumerate Four common causes of thrombocytopenia

4.Hemophilia B. Answer in single sentence: (4x½=2)

5.Name two anticoagulant and their use

6.Name two common causes for thrombocytopenia

7.Anticoagulants used to preserve blood in blood bank. Answer in single sentence: (4x½=2)

8.Clotting time

9.List two hematological evidences of DIC

1.(A): von Willebrand factor is synthesized by Hepatocytes

• (R): von Willebrand factor is a carrier protein for factor VIII
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.Fibrin degradation products have

• a) Potent anticoagulant effect
• b) Platelet aggregation effect
• c) Prothrombotic effect
• d) Endothelial activation effect

3.In Bernard-Soulier Syndrome there is defect of platelet

• a) Adhesion
• b) Aggregation
• c) Secretion
• d) Activation

4.Prolonged Bleeding time is seen in

• 1) Thrombocytopenia
• 2) Von Willebrand’s disease
• 3) Haemophilia A
• 4) Aspirin therapy
• a) 1,2 and 3 are correct
• b) 2, 3 and 4 are correct
• c) 1, 3 and 4 are correct
• d) 1, 2 and 4 are correct

5.What is your most probable clinical diagnosis

• a) Acute Leukaemia
• b) Immune thrombocytopenia
• c) Disseminated Intravascular coagulation
• d) Anaphylactic shock

6.Which one of the following investigation is diagnostic

• a) Platelet Count
• b) Prothrombin time
• c) Thrombin Time
• d) D – dimer test

7.(A): Dengue hemorrhagic fever causes thrombocytopenia

• (R): Increase in immune destruction of platelets
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct