Liver — Hepatitis & Cirrhosis

1.Define and classify cirrhosis. Describe the pathogenesis and morphology of alcoholic liver disease

2.Define and classify cirrhosis of liver. Discuss pathogenesis, histopathology and complications of alcoholic cirrhosis

3.Discuss Hepatitis B infection under the following headings:-

• a) Clinical features
• b) Gross and microscopic changes in liver
• c) Complications

1.Changes in serum markers and liver histology in Hepatitis B infection

2.A 45 years old male was admitted with complaints of yellowish discoloration of eyes and distension of abdomen since 15 days. USG abdomen shows contracted liver with loss of architecture and splenomegaly. Patient is a chronic alcoholic since 15 years. Answer the following: • What is your most probable diagnosis. • Describe the gross and microscopic features of the organs involved. • Name the laboratory investigation to be done in this case and the expected variation in this values • List three complications of the above condition

1.Explain the macroscopic and microscopic changes seen in alcoholic cirrhosis with a labeled diagram

2.Morphology of alcoholic hepatitis

3.Chronic active hepatitis etiology and microscopic picture

4.Etiopathogenesis of cirrhosis

5.Chronic venous congestive liver

6.Fatty liver

1.Nutmeg liver

2.Four Causes of Cirrhosis of Liver Answer in single sentence: (4x½=2)

3.Mallory body

4.…………… bodies are commonly seen in alcoholic cirrhosis

5.Microscopy of alcoholic liver disease Answer in single sentence: (4x½=2)

6.Laboratory diagnosis of Hepatitis

7.Name a condition where “nutmeg liver pattern” is seen

8.What is the appearance of hepatocytes in hepatitis B infection

9.Complications of cirrhosis

10.Name the condition in which Gamna Gandy bodies are seen

11.Name two causes of fatty liver

12.Grey hepatisation

13.Mallory bodies

14.Mention two causes of cirrhosis

15.Cirrhosis

1.(A) Hepatitis E virus is the most common cause for transfusion associated Hepatitis (R) Hepatitis E infection in pregnancy carries higher mortality

• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.(A) Hepatocytes show PASD positive cytoplasmic globular inclusions in Alpha -1 -Antitrypsin deficiency. (R) Alpha-1-Antitrypsin deficiency is caused by mutations that lead to misfolding of Alpha -1-Antitrypsin

• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct