Hypersensitivity

1.Type II hypersensitivity reaction

2.A person after 20 minutes of vaccine administration develops generalized pruritus, difficulty in breathing, hypotension and vomiting.

• a) What is the most probable diagnosis of this patient.
• b) Describe the pathogenesis of this condition

3.Biologic mechanism of Type II hypersensitivity reaction. Give examples of four diseases with type II hypersensitivity as the mechanism of pathologic injury

1.Type III hypersensitivity reaction

2.Hypersensitivity reactions

3.Anaphylaxis

4.Antineutrophil cytoplasmic antibodies

5.Mediators of immediate hypersensitivity

1.Define delayed hypersensitivity reaction

2.Name four type III hypersensitivity reactions

3.Anaphylaxis

1.(A): IL-4 and IL-13 causes activation of M2 macrophages

• (R): M2 macrophages are not microbicidal
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.(A): Type-1 hypersensitivity reaction causes laryngeal edema

• (R): Histamine causes increased vascular permeability and pain
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

3.The hypersensitivity reaction associated with this condition is

• a) Type-I
• b) Type-II
• c) Type-III
• d) Type-IV

4.Which of the following cytokine is NOT secreted by TH2 cells

• a) IL-4
• b) IL-5
• c) IFN-Gamma
• d) IL-13

5.Which of the following immunoglobulins play a major role in this reaction

• a) Ig A
• b) Ig G
• c) Ig E
• d) Ig M