Breast Pathology

1.A 50-year-old nulliparous female presents with a hard lesion of the right breast that she had noticed 2 weeks ago. Clinical examination reveals puckering of the overlying skin and retraction of the nipple along with a 3 cm hard mass in the upper outer quadrant of the right breast. 3 hard masses are palpable in the right axilla. On questioning the patient reveals a weight loss of 7kg in the last 2 months. Mammogram reveals a

• a) 4 cm mass with irregular spiculated margins and increased density compared to the surrounding breast tissue.
• b) What is your diagnosis. Justify it
• c) What is the gross and histology of this lesion
• d) List the major prognostic and predictive markers
• e) Discuss the mode of spread of this disease

1.Risk factors and prognostic factors of carcinoma breast

2.Prognostic and predictive factors for breast carcinoma

3.Explain the molecular basis of classification and prognostic features of Carcinoma breast

4.A 50 years old female presented with painless lump in right breast since 6 months, gradually increasing in size. O/E: A firm to hard lump fixed to underlying structures and skin was present. Ipsilateral axillary lymph nodes were palpable. Answer the following:  What is the clinical diagnosis  Describe the etiological factors and morphology of the lesion.  Name two prognostic factors

5.A 48 years female nullipara presented with hard fixed lump of size 6x4x4 cm in the upper outer quadrant of right breast with right axillary lymphadenopathy. Answer the following  What is your diagnosis.  Enumerate four histological types.  Discuss in detail six prognostic and predictive factors

1.Comedo DCIS Answer in single sentence: (4x½=2)

2.Pagets disease of nipple

3.Two prognostic factors in breast carcinoma

4.Fibro adenoma breast

1.All are true statement about HER2 positive invasive carcinoma breast EXCEPT

• a) More common in young women
• b) Metastasize early to viscera and brain
• c) Targeted therapy available
• d) Most common carcinoma associated with BRCA 2 germline mutation

2.All of the following are prognostic parameters in the evaluation of Breast Carcinoma EXCEPT

• a) Tumour grade
• b) Axillary Lymphnode status
• c) Hormone Receptor status
• d) Parity status

3.Morphologic type of invasive carcinoma breast with excellent prognosis

• a) Tubular carcinoma
• b) Lobular carcinoma
• c) Medullary carcinoma
• d) Mucinous carcinoma