Cervical & Uterine Pathology

1.A 42-year-old woman, who did not have a medical checkup for many years, noted the onset of post coital bleeding. On examination, she was found to have an ulcerated growth on the anterior lip of cervix.

• a) What is the likely diagnosis and why.
• b) How could this disease have been detected early.
• c) Discuss the etiopathogenesis of this disease.
• d) Describe the microscopic types of this lesion

2.Classify the tumors of the uterus. Discuss the pathology of leiomyoma. Add a note on secondary changes in leiomyoma

1.Pathogenesis and screening methods of carcinoma cervix

2.A 62-year-old cachectic postmenopausal female presented to the Gynaecology clinic with a history of bleeding per vagina. Per speculum examination showed an ulcero- proliferative growth involving the cervix which bleeds on touch along with foul smelling vaginal discharge.

• a) What is the most probable diagnosis.
• b) Discuss the aetiopathogenesis of this condition.
• c) Briefly describe the methods of screening for this lesion

3.A 55-year-old female with complaints of foul smelling white discharge per vagina of two-month duration, on PV examination friable small growth noted in the cervix which bleeds on touch.

• a) What is the provisional clinical diagnosis.
• b) Name two investigations to confirm the diagnosis.
• c) Enumerate the risk factors and aetiopathogenisis of this disease

4.Risk factors and classification of endometrial carcinoma

5.A 50-year old female presented with bleeding per vagina. Per speculum examination showed an ulceroproliferative lesion involving the external os, which bleeds on touch. Answer the following.  What is the clinical diagnosis.  Describe the etiopathogenesis and morphology of the lesion.  Screening method for this condition

6.55 years old female presented with postmenopausal bleeding and foul smelling discharge. P/V examination revealed unhealthy, indurated ulcerated cervix. Answer the following. • What is the provisional diagnosis • How do you establish the diagnosis • Describe microscopic picture of the lesion • Mention the prognosis of the lesion

1.Cervical intraepithelial neoplasia

2.Etiopathogenesis of cervical carcinoma

1.Define endometriosis

2.Pap smear. Answer in single sentence: (4x½=2)

3.Sites of ectopic pregnancy

4.What is endometriosis

5.Adenomyosis

6.Clinico-pathological features of leiomyoma

7.Name two premalignant lesions of carcinoma cervix

1.All are true about carcinoma endometrium EXCEPT

• a) Commonly seen in post menopausal women
• b) Unopposed estrogen stimulation leads to serous carcinoma
• c) Endometrioid type is associated with increased signaling through P13K/AKT pathway
• d) Serous carcinoma is aggressive than endometrioid type

2.Examples for hypertrophy includes

• 1) Body builders
• 2) Myometrium of pregnant uterus
• 3) Fibroadenoma
• 4) Left ventricle in Hypertension
• a) 1, 2, 3
• b) 2, 3, 4
• c) 3, 4, 1
• d) 1, 2, 4