Carcinogenesis & Oncogenes

1.Chemical carcinogenesis

2.Role of Chemical Carcinogens

3.Oncogenic DNA viruses

4.Microbial carcinogenesis

1.Retinoblastoma

2.Discuss chemical carcinogenesis with examples

3.Viral oncogenes

4.Radiation and cancer

5.Oncogenes

1.Name two oncogenic viruses and the malignancy they cause

2.Proto oncogene

3.What is the genetic basis of Retinoblastoma

4.Retinoblastoma

5.Stem cell

6.Name four carcinogenic viruses

1.(A): More than 70% of human cancers have a defect in p53 gene

• (R): p53 plays a central role in maintaining the integrity of the genome
• a) Both A & R are correct and R is the reason for A
• b) Both A & R are correct but R is not reason for A
• c) A is correct R is incorrect
• d) A is incorrect R is correct

2.N-myc is a

• a) Signal transduction factor
• b) Growth factor
• c) Growth factor receptor
• d) Nuclear transcription factor